Standard
Cholesterol, total
CYP7A1 · rs2081687
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Cholesterol, total — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cholesterol, total.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cholesterol, total compared to the general population.
Source
Discovery and refinement of loci associated with lipid levels
Willer CJ,
Schmidt EM,
Sengupta S,
Peloso GM,
Gustafsson S,
Kanoni S,
Ganna A,
Chen J,
Buchkovich ML,
Mora S,
Beckmann JS,
Bragg-Gresham JL
and 247 more — show all
Chang HY,
Demirkan A,
Den Hertog HM,
Do R,
Donnelly LA,
Ehret GB,
Esko T,
Feitosa MF,
Ferreira T,
Fischer K,
Fontanillas P,
Fraser RM,
Freitag DF,
Gurdasani D,
Heikkilä K,
Hyppönen E,
Isaacs A,
Jackson AU,
Johansson Å,
Johnson T,
Kaakinen M,
Kettunen J,
Kleber ME,
Li X,
Luan J,
Lyytikäinen LP,
Magnusson PKE,
Mangino M,
Mihailov E,
Montasser ME,
Müller-Nurasyid M,
Nolte IM,
O'Connell JR,
Palmer CD,
Perola M,
Petersen AK,
Sanna S,
Saxena R,
Service SK,
Shah S,
Shungin D,
Sidore C,
Song C,
Strawbridge RJ,
Surakka I,
Tanaka T,
Teslovich TM,
Thorleifsson G,
Van den Herik EG,
Voight BF,
Volcik KA,
Waite LL,
Wong A,
Wu Y,
Zhang W,
Absher D,
Asiki G,
Barroso I,
Been LF,
Bolton JL,
Bonnycastle LL,
Brambilla P,
Burnett MS,
Cesana G,
Dimitriou M,
Doney ASF,
Döring A,
Elliott P,
Epstein SE,
Ingi Eyjolfsson G,
Gigante B,
Goodarzi MO,
Grallert H,
Gravito ML,
Groves CJ,
Hallmans G,
Hartikainen AL,
Hayward C,
Hernandez D,
Hicks AA,
Holm H,
Hung YJ,
Illig T,
Jones MR,
Kaleebu P,
Kastelein JJP,
Khaw KT,
Kim E,
Klopp N,
Komulainen P,
Kumari M,
Langenberg C,
Lehtimäki T,
Lin SY,
Lindström J,
Loos RJF,
Mach F,
McArdle WL,
Meisinger C,
Mitchell BD,
Müller G,
Nagaraja R,
Narisu N,
Nieminen TVM,
Nsubuga RN,
Olafsson I,
Ong KK,
Palotie A,
Papamarkou T,
Pomilla C,
Pouta A,
Rader DJ,
Reilly MP,
Ridker PM,
Rivadeneira F,
Rudan I,
Ruokonen A,
Samani N,
Scharnagl H,
Seeley J,
Silander K,
Stančáková A,
Stirrups K,
Swift AJ,
Tiret L,
Uitterlinden AG,
van Pelt LJ,
Vedantam S,
Wainwright N,
Wijmenga C,
Wild SH,
Willemsen G,
Wilsgaard T,
Wilson JF,
Young EH,
Zhao JH,
Adair LS,
Arveiler D,
Assimes TL,
Bandinelli S,
Bennett F,
Bochud M,
Boehm BO,
Boomsma DI,
Borecki IB,
Bornstein SR,
Bovet P,
Burnier M,
Campbell H,
Chakravarti A,
Chambers JC,
Chen YI,
Collins FS,
Cooper RS,
Danesh J,
Dedoussis G,
de Faire U,
Feranil AB,
Ferrières J,
Ferrucci L,
Freimer NB,
Gieger C,
Groop LC,
Gudnason V,
Gyllensten U,
Hamsten A,
Harris TB,
Hingorani A,
Hirschhorn JN,
Hofman A,
Hovingh GK,
Hsiung CA,
Humphries SE,
Hunt SC,
Hveem K,
Iribarren C,
Järvelin MR,
Jula A,
Kähönen M,
Kaprio J,
Kesäniemi A,
Kivimaki M,
Kooner JS,
Koudstaal PJ,
Krauss RM,
Kuh D,
Kuusisto J,
Kyvik KO,
Laakso M,
Lakka TA,
Lind L,
Lindgren CM,
Martin NG,
März W,
McCarthy MI,
McKenzie CA,
Meneton P,
Metspalu A,
Moilanen L,
Morris AD,
Munroe PB,
Njølstad I,
Pedersen NL,
Power C,
Pramstaller PP,
Price JF,
Psaty BM,
Quertermous T,
Rauramaa R,
Saleheen D,
Salomaa V,
Sanghera DK,
Saramies J,
Schwarz PEH,
Sheu WH,
Shuldiner AR,
Siegbahn A,
Spector TD,
Stefansson K,
Strachan DP,
Tayo BO,
Tremoli E,
Tuomilehto J,
Uusitupa M,
van Duijn CM,
Vollenweider P,
Wallentin L,
Wareham NJ,
Whitfield JB,
Wolffenbuttel BHR,
Ordovas JM,
Boerwinkle E,
Palmer CNA,
Thorsteinsdottir U,
Chasman DI,
Rotter JI,
Franks PW,
Ripatti S,
Cupples LA,
Sandhu MS,
Rich SS,
Boehnke M,
Deloukas P,
Kathiresan S,
Mohlke KL,
Ingelsson E,
Abecasis GR
Nature genetics · 2013 · PMID 24097068 · open access
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs2081687
What is rs2081687?
rs2081687 is a single position in the genome, in or near the CYP7A1 gene. Published research associates it with cholesterol, total. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs2081687?
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (3 papers), blood sugar and insulin (1 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs2081687 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2081687 come from?
GWAS Catalog, Nat Genet 2013, PMID:24097068. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants