Sensitive

Statin muscle-side-effect risk

SLCO1B1 · rs4149056

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Where this position leads

Condition: Statin-Associated Muscle Symptoms and SLCO1B1

Drug: Statins

rs4149056 Condition: Statin-Associated Muscle Symptoms and SLCO1B1 Statin-Associated Muscle Symptoms and… Condition Drug: Statins Statins Drug rs4149056 SLCO1B1

What each result means

C/C Published research associates this genotype with substantially reduced SLCO1B1 transporter function — associated with a clinically meaningful elevated risk of statin-associated muscle side effects (myopathy), particularly at higher simvastatin doses.
T/C Published research associates this genotype with reduced SLCO1B1 transporter function, which can raise blood levels of some statins (notably simvastatin) and is associated with a moderately elevated risk of muscle-related side effects.
T/T Typical SLCO1B1 transporter function in published research — no added risk from this variant for statin-associated muscle side effects.
This is a pharmacogenomic finding with clinical dosing guidelines (CPIC). If you are prescribed a statin, share this result with your doctor or pharmacist — it may affect which statin or dose is recommended. Do not stop or change any medication on your own.

Source: SEARCH Collaborative Group, Link et al. 2008, New England Journal of Medicine — SLCO1B1 variants and statin-induced myopathy.

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