SLCO1B1 · rs4149056
Where this position leads
Condition: Statin-Associated Muscle Symptoms and SLCO1B1
Drugs: Statins, Ticagrelor
Supplement: Coenzyme Q10
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
drug response for Rotor syndrome, simvastatin acid response - Metabolism/PK, Gilbert syndrome, simvastatin response - Toxicity, hmg coa reductase inhibitors response - Toxicity and 13 more; reviewed by expert panel (3 of 4 stars, 11 submitters), last evaluated 2022-02-15.
ClinVar record 37346 NM_006446.5(SLCO1B1):c.521T>C (p.Val174Ala)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
2026-05-01 · Dr. Akinyemi Oni-Orisan, UCSF, published in Clinical Pharmacology & Therapeutics (CPIC guideline update, May 2026 issue)
CPIC updated its SLCO1B1 allele functionality table (used to guide statin dosing, alongside SLCO1B1 rs4149056/*5, profiled on this site) after finding two variants enriched in Sub-Saharan African ancestry -- rs59502379 (part of *9/*31) and rs77271279 (*41) -- carry even larger statin-myopathy risk than the well-known rs4149056 variant: odds ratios of 2.45 and 3.27 for muscle injury, including a documented rhabdomyolysis case. A genotyping panel built only around rs4149056 would have missed both -- exactly the equity gap this update corrects.
rs4149056 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with statin muscle-side-effect risk. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Statin-Associated Muscle Symptoms and SLCO1B1. The research behind each link, and its sources, are set out on that condition page.
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (21 papers), heart and circulation (14 papers), blood sugar and insulin (9 papers), kidneys (3 papers), fertility (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
SEARCH Collaborative Group, Link et al. 2008, New England Journal of Medicine — SLCO1B1 variants and statin-induced myopathy. PMID 18650507. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Statin muscle-side-effect risk (rs4149056). MyGeneLog™. https://www.mygenelog.com/variants/rs4149056