MC4R · rs12970134
Where this position leads
Condition: Obesity and Body Weight
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 2,684 Indian Asian ancestry male individuals; replicated in 7,394 Indian Asian ancestry individuals, 4,561 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.88 cm higher (95% confidence interval 0.59-1.17); p = 2 × 10−9.
How common The A allele had a frequency of about 36% in the people studied.
Where it sits Chromosome 18, band 18q21.32 — between genes, 19 kb from LOC342784.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs12970134 is a single position in the genome, in or near the MC4R gene. Published research associates it with waist circumference and related phenotypes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (19 papers), exercise and muscle (7 papers), cholesterol and blood fats (4 papers), alcohol and the flush (1 papers), fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2008, PMID:18454146. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Waist circumference and related phenotypes (rs12970134). MyGeneLog™. https://www.mygenelog.com/variants/rs12970134