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Waist circumference and related phenotypes

MC4R · rs12970134

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Waist circumference and related phenotypes compared to the general population. (GWAS Catalog, Nat Genet 2008, PMID:18454146)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Waist circumference and related phenotypes. (GWAS Catalog, Nat Genet 2008, PMID:18454146)

G/G Published research associates this genotype with typical/baseline likelihood of Waist circumference and related phenotypes — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2008, PMID:18454146)

Source: GWAS Catalog, Nat Genet 2008, PMID:18454146

Questions about rs12970134

What is rs12970134?

rs12970134 is a single position in the genome, in or near the MC4R gene. Published research associates it with waist circumference and related phenotypes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12970134 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12970134 come from?

GWAS Catalog, Nat Genet 2008, PMID:18454146. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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