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HDL cholesterol

ABCA1 · rs1883025

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs1883025 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Topic: Cholesterol and blood fats Cholesterol and blood fats Topic Topic: Heart and circulation Heart and circulation Topic rs1883025 rs1883025 ABCA1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 19,840 European ancestry individuals; replicated in Up to 20,623 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.08 s.d. lower (95% confidence interval 0.04-0.12); p = 1 × 10−9.

How common The T allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 9, band 9q31.1 — in an intron of ABCA1.

What each result means

C/C No copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
T/T Two copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1883025

What is rs1883025?

rs1883025 is a single position in the genome, in or near the ABCA1 gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1883025 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1883025?

Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (8 papers), heart and circulation (6 papers), exercise and muscle (1 papers), short-sightedness and screens (1 papers), infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1883025 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1883025 come from?

GWAS Catalog, Nat Genet 2008, PMID:19060906. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

HDL cholesterol (rs1883025). MyGeneLog™. https://www.mygenelog.com/variants/rs1883025

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