Standard
LDL cholesterol
CELSR2 · rs12740374
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
G/G
Published research associates this genotype with typical/baseline likelihood of LDL cholesterol — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2008, PMID:19060906)
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with LDL cholesterol. (GWAS Catalog, Nat Genet 2008, PMID:19060906)
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of LDL cholesterol compared to the general population. (GWAS Catalog, Nat Genet 2008, PMID:19060906)
Source
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan S,
Willer CJ,
Peloso GM,
Demissie S,
Musunuru K,
Schadt EE,
Kaplan L,
Bennett D,
Li Y,
Tanaka T,
Voight BF,
Bonnycastle LL
and 49 more — show all
Jackson AU,
Crawford G,
Surti A,
Guiducci C,
Burtt NP,
Parish S,
Clarke R,
Zelenika D,
Kubalanza KA,
Morken MA,
Scott LJ,
Stringham HM,
Galan P,
Swift AJ,
Kuusisto J,
Bergman RN,
Sundvall J,
Laakso M,
Ferrucci L,
Scheet P,
Sanna S,
Uda M,
Yang Q,
Lunetta KL,
Dupuis J,
de Bakker PI,
O'Donnell CJ,
Chambers JC,
Kooner JS,
Hercberg S,
Meneton P,
Lakatta EG,
Scuteri A,
Schlessinger D,
Tuomilehto J,
Collins FS,
Groop L,
Altshuler D,
Collins R,
Lathrop GM,
Melander O,
Salomaa V,
Peltonen L,
Orho-Melander M,
Ordovas JM,
Boehnke M,
Abecasis GR,
Mohlke KL,
Cupples LA
Nature genetics · 2009 · PMID 19060906
Questions about rs12740374
What is rs12740374?
rs12740374 is a single position in the genome, in or near the CELSR2 gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12740374 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12740374 come from?
GWAS Catalog, Nat Genet 2008, PMID:19060906. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants