Gene Knowledge Graph
UTC
Standard

Vitamin D levels

GC · rs2282679

Where this position leads

Condition: Vitamin D Deficiency and the GC Gene

Supplement: Vitamin D

rs2282679 Condition: Vitamin D Deficiency and the GC Gene Vitamin D Deficiency and the GC Gene Condition Supplement: Vitamin D Vitamin D Supplement Topic: Vitamins and nutrient levels Vitamins and nutrient levels Topic Topic: Bones and fractures Bones and fractures Topic Topic: Blood sugar and insulin Blood sugar and insulin Topic rs2282679 rs2282679 GC

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What each result means

G/G Published research associates this genotype with lower average circulating vitamin D levels, independent of diet or sun exposure — one of the strongest and most replicated genetic associations with vitamin D status.
T/G One copy of the variant. Published research associates this genotype with somewhat lower average circulating vitamin D (25-hydroxyvitamin D) levels.
T/T Typical vitamin D binding protein levels in published research — no added association with lower circulating vitamin D from this variant.
A blood test (25-hydroxyvitamin D) is the reliable way to know your actual level — this genotype only describes a population-level tendency. Talk to a doctor before starting supplementation.
Source
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD
and 64 more — show all
O'Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Järvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hyppönen E, Spector TD
Lancet (London, England) · 2010 · PMID 20541252

What people read about alongside this

Vitamins and nutrient levels87 Bones and fractures14 Blood sugar and insulin13 Infection and immunity5 Exercise and muscle5 Heart and circulation4 Liver3 Sport and performance2 Cholesterol and blood fats2 Alcohol and the flush2 Longevity and ageing2 Menopause1 Learning and focus1 Kidneys1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2282679

What is rs2282679?

rs2282679 is a single position in the genome, in or near the GC gene. Published research associates it with vitamin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2282679 linked to?

On MyGeneLog this position is linked to Vitamin D Deficiency and the GC Gene. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs2282679?

Subjects that appear in the title or abstract of the same papers as this rsID include vitamins and nutrient levels (87 papers), bones and fractures (14 papers), blood sugar and insulin (13 papers), infection and immunity (5 papers), exercise and muscle (5 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2282679 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2282679 come from?

Wang et al. 2010, The Lancet — common genetic determinants of vitamin D insufficiency: a genome-wide association study. PMID 20541252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Vitamin D levels (rs2282679). MyGeneLog™. https://www.mygenelog.com/variants/rs2282679

← See all variants