TERT · rs2736100
Where this position leads
Condition: Lung Cancer
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 1,004 Japanese ancestry cases, 1,900 Japanese ancestry controls; replicated in 1,094 East Asian ancestry cases, 9,148 East Asian ancestry controls.
The effect Each copy of the C allele carried 1.27 times the odds of Lung adenocarcinoma (95% confidence interval 1.19-1.37); p = 3 × 10−11.
How common The C allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 5, band 5p15.33 — in an intron of TERT.
What ClinVar records
Classification
Benign for Chronic osteomyelitis, Chronic obstructive pulmonary disease, Interstitial lung disease 2, Combined pulmonary fibrosis-emphysema syndrome, Dyskeratosis congenita, autosomal dominant 2 and 2 more; criteria provided, single submitter (1 of 4 stars, 3 submitters), last evaluated 2026-02-04.
ClinVar record 375480 NM_198253.3(TERT):c.1574-3777G>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs2736100 is a single position in the genome, in or near the TERT gene. Published research associates it with lung adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (3 papers), smoking and vaping (2 papers), heart and circulation (1 papers), alcohol and the flush (1 papers), depression and stress (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2010, PMID:20871597. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung adenocarcinoma (rs2736100). MyGeneLog™. https://www.mygenelog.com/variants/rs2736100