Sensitive

Crohn's disease

HLA-DQA2 · rs1799964

Where this position leads

Condition: Crohn's Disease

rs1799964 Condition: Crohn's Disease Crohn's Disease Condition Topic: Infection and immunity Infection and immunity Topic Topic: Blood sugar and insulin Blood sugar and insulin Topic Topic: Exercise and muscle Exercise and muscle Topic rs1799964 rs1799964 HLA-DQA2

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 6,333 European ancestry cases, 15,056 European ancestry controls; replicated in 15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry trios.

The effect Each copy of the C allele carried 1.19 times the odds of Crohn's disease (95% confidence interval 1.13-1.25); p = 4 × 10−11.

How common The C allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 0.2 kb from LTA.

What each result means

C/C Two copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/T No copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1799964

What is rs1799964?

rs1799964 is a single position in the genome, in or near the HLA-DQA2 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1799964 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1799964?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (8 papers), exercise and muscle (5 papers), blood sugar and insulin (5 papers), depression and stress (4 papers), allergies (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1799964 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1799964 come from?

GWAS Catalog, Nat Genet 2010, PMID:21102463. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Crohn's disease (rs1799964). MyGeneLog™. https://www.mygenelog.com/variants/rs1799964

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