Sensitive

Type 2 diabetes

KCNQ1 · rs2237892

Where this position leads

Condition: Type 2 Diabetes

rs2237892 Condition: Type 2 Diabetes Type 2 Diabetes Condition Topic: Blood sugar and insulin Blood sugar and insulin Topic Topic: Heart and circulation Heart and circulation Topic rs2237892 rs2237892 KCNQ1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 519 Japanese ancestry cases, 503 Japanese ancestry controls; replicated in 5,110 Japanese ancestry cases, 6,867 Japanese ancestry controls.

The effect Each copy of the C allele carried 1.33 times the odds of Type 2 diabetes (95% confidence interval 1.27-1.41); p = 1 × 10−26.

How common The C allele had a frequency of about 59% in the people studied.

Where it sits Chromosome 11, band 11p15.4 — in an intron of KCNQ1.

What each result means

C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/T No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2237892

What is rs2237892?

rs2237892 is a single position in the genome, in or near the KCNQ1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2237892 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs2237892?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (73 papers), heart and circulation (4 papers), alcohol and the flush (1 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2237892 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2237892 come from?

GWAS Catalog, Diabetes 2009, PMID:19401414. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs2237892). MyGeneLog™. https://www.mygenelog.com/variants/rs2237892

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