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Hemoglobin

PRKAG2 · rs10224002

Where this position leads

Condition: Blood Cell Counts

rs10224002 Condition: Blood Cell Counts Blood Cell Counts Condition rs10224002 rs10224002 PRKAG2

What the study found

Who was studied 24,167 European ancestry individuals; replicated in 9,456 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.07 g/dl higher (95% confidence interval 0.05-0.09); p = 3 × 10−15.

Where it sits Chromosome 7, band 7q36.1 — in an intron of PRKAG2.

What each result means

A/A No copy of the version the research linked to Hemoglobin. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Hemoglobin. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Hemoglobin. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA, Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T
and 50 more — show all
Yang Q, Tanaka T, Jaffe A, Bis JC, Verwoert GC, Teumer A, Fox CS, Guralnik JM, Ehret GB, Rice K, Felix JF, Rendon A, Eiriksdottir G, Levy D, Patel KV, Boerwinkle E, Rotter JI, Hofman A, Sambrook JG, Hernandez DG, Zheng G, Bandinelli S, Singleton AB, Coresh J, Lumley T, Uitterlinden AG, Vangils JM, Launer LJ, Cupples LA, Oostra BA, Zwaginga JJ, Ouwehand WH, Thein SL, Meisinger C, Deloukas P, Nauck M, Spector TD, Gieger C, Gudnason V, van Duijn CM, Psaty BM, Ferrucci L, Chakravarti A, Greinacher A, O'Donnell CJ, Witteman JC, Furth S, Cushman M, Harris TB, Lin JP
Nature genetics · 2009 · PMID 19862010 · open access

What people read about alongside this

Heart and circulation1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10224002

What is rs10224002?

rs10224002 is a single position in the genome, in or near the PRKAG2 gene. Published research associates it with hemoglobin. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10224002 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10224002?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10224002 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10224002 come from?

GWAS Catalog, Nat Genet 2009, PMID:19862010. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hemoglobin (rs10224002). MyGeneLog™. https://www.mygenelog.com/variants/rs10224002

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