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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 19,840 European ancestry individuals; replicated in Up to 20,623 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.05 s.d. lower (95% confidence interval -0.03-0.13); p = 2 × 10−8.
How common The C allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 19, band 19p13.11 — in an intron of SUGP1.
What each result means
C/CTwo copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
T/TNo copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10401969
What is rs10401969?
rs10401969 is a single position in the genome, in or near the NCAN gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10401969 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10401969?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (4 papers), cholesterol and blood fats (2 papers), alcohol and the flush (2 papers), liver (2 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10401969 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10401969 come from?
GWAS Catalog, Nat Genet 2008, PMID:19060906. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 5232239122226Reads by AI crawlersClaude3ChatGPT2Google · Gemini2Perplexity3Meta AI9Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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