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Vitamin D levels

NADSYN1 · rs3829251

Where this position leads

Condition: Vitamin D Deficiency and the GC Gene

rs3829251 Condition: Vitamin D Deficiency and the GC Gene Vitamin D Deficiency and the GC Gene Condition Topic: Vitamins and nutrient levels Vitamins and nutrient levels Topic Topic: Bones and fractures Bones and fractures Topic rs3829251 rs3829251 NADSYN1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 4,501 European ancestry individuals; replicated in 2,221 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.18 lower (95% confidence interval 0.12-0.24); p = 3 × 10−9.

How common The A allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 11, band 11q13.4 — in an intron of NADSYN1.

What each result means

A/A Two copies of the version the research linked to Vitamin D levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Vitamin D levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Vitamin D levels. This is the starting point the study compared everyone against.
Source
Genome-wide association study of circulating vitamin D levels
Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, Gallicchio L, Jacobs EJ, Ascherio A, Helzlsouer K, Jacobs KB, Li Q, Weinstein SJ
and 9 more — show all
Purdue M, Virtamo J, Horst R, Wheeler W, Chanock S, Hunter DJ, Hayes RB, Kraft P, Albanes D
Human molecular genetics · 2010 · PMID 20418485 · open access

What people read about alongside this

Vitamins and nutrient levels11 Bones and fractures3 Heart and circulation2 Infection and immunity1 Risk-taking and impulsivity1 Blood sugar and insulin1 Sport and performance1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3829251

What is rs3829251?

rs3829251 is a single position in the genome, in or near the NADSYN1 gene. Published research associates it with vitamin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3829251 linked to?

On MyGeneLog this position is linked to Vitamin D Deficiency and the GC Gene. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3829251?

Subjects that appear in the title or abstract of the same papers as this rsID include vitamins and nutrient levels (11 papers), bones and fractures (3 papers), heart and circulation (2 papers), infection and immunity (1 papers), risk-taking and impulsivity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3829251 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3829251 come from?

GWAS Catalog, Hum Mol Genet 2010, PMID:20418485. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Vitamin D levels (rs3829251). MyGeneLog™. https://www.mygenelog.com/variants/rs3829251

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