SLC18A1 · rs326
Where this position leads
Condition: High Triglycerides
What the study found
Who was studied 1,005 European ancestry male individuals, 1,006 Indian Asian ancestry male individuals; replicated in 6,827 European ancestry individuals, 2,528 Mexican ancestry individuals, 1,181 Indian Asian ancestry female individuals.
The effect Each copy of the A allele shifted the measure 6.6 % higher (95% confidence interval 3.66-9.54); p = 5 × 10−12.
How common The A allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 8, band 8p21.3 — in an intron of LPL.
What ClinVar records
Classification
Benign for High density lipoprotein cholesterol level quantitative trait locus 11; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2019-04-08.
ClinVar record 1559 NM_000237.3(LPL):c.1323-187A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs326 is a single position in the genome, in or near the SLC18A1 gene. Published research associates it with triglycerides. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), cholesterol and blood fats (1 papers), exercise and muscle (1 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2008, PMID:18193046. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Triglycerides (rs326). MyGeneLog™. https://www.mygenelog.com/variants/rs326