2 61426210222130Reads by AI crawlersClaude4ChatGPT2Google · Gemini6Perplexity2Meta AI10Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others30Total61Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 95,454 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 2 mg/dL higher (95% confidence interval 1.57-2.43); p = 2 × 10−22.
How common The A allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 16, band 16q22.2 — in an intron of HPR.
What each result means
A/ATwo copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
G/GNo copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs2000999
What is rs2000999?
rs2000999 is a single position in the genome, in or near the HPR gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2000999 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs2000999?
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (3 papers), blood sugar and insulin (2 papers), natural selection (1 papers), heart and circulation (1 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs2000999 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2000999 come from?
GWAS Catalog, Nature 2010, PMID:20686565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 61426210222130Reads by AI crawlersClaude4ChatGPT2Google · Gemini6Perplexity2Meta AI10Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others30Total61Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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