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Bilirubin levels

UGT1A1 · rs6742078

Where this position leads

Drugs: Atazanavir, Irinotecan

What the study found

Who was studied 9,464 individuals.

The effect Each copy of the T allele shifted the measure 0.23 umol/l higher (95% confidence interval 0.21-0.25).

How common The T allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 2, band 2q37.1 — in an intron of UGT1A7.

What ClinVar records

Classification Benign; association for BILIRUBIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1, Gilbert syndrome; no assertion criteria provided (0 of 4 stars, 2 submitters), last evaluated 2019-05-01. ClinVar record 12289 NM_000463.3(UGT1A1):c.864+2842G>T

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G No copy of the version the research linked to Bilirubin levels. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Bilirubin levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Bilirubin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association meta-analysis for total serum bilirubin levels

Johnson AD, Kavousi M, Smith AV, Chen MH, Dehghan A, Aspelund T, Lin JP, van Duijn CM, Harris TB, Cupples LA, Uitterlinden AG, Launer L

and 7 more — show all

Hofman A, Rivadeneira F, Stricker B, Yang Q, O'Donnell CJ, Gudnason V, Witteman JC

Human molecular genetics · 2009 · PMID 19414484

What people read about alongside this

Heart and circulation2 Blood sugar and insulin1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs6742078

What is rs6742078?

rs6742078 is a single position in the genome, in or near the UGT1A1 gene. Published research associates it with bilirubin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs6742078 affect how medicines work?

UGT1A1 carries pharmacogenomic findings for Atazanavir, Irinotecan. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs6742078?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (2 papers), blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs6742078 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6742078 come from?

GWAS Catalog, Hum Mol Genet 2009, PMID:19414484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Bilirubin levels (rs6742078). MyGeneLog™. https://www.mygenelog.com/variants/rs6742078

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