9 5313844122424Reads by AI crawlersClaude1ChatGPT3Google · Gemini8Perplexity4Meta AI4Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)4ByteDance (Doubao)4Others24Total53Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 931 cases, 1,104 controls; replicated in 1,338 cases, 2,003 controls.
The effect
Each copy of the G allele carried 2.94 times the odds of Alzheimer's disease (late onset) (95% confidence interval 2.48-3.47); p = 5 × 10−36.
How common The G allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — in an intron of TOMM40.
What each result means
A/ANo copy of the version the research linked to Alzheimer's disease (late onset). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Alzheimer's disease (late onset). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Alzheimer's disease (late onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs2075650
What is rs2075650?
rs2075650 is a single position in the genome, in or near the APOE gene. Published research associates it with alzheimer's disease (late onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2075650 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE), Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs2075650 affect how medicines work?
APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
What do people read about alongside rs2075650?
Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (6 papers), longevity and ageing (6 papers), learning and focus (5 papers), heart and circulation (3 papers), personality (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs2075650 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2075650 come from?
GWAS Catalog, PLoS Genet 2010, PMID:20885792. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
9 5313844122424Reads by AI crawlersClaude1ChatGPT3Google · Gemini8Perplexity4Meta AI4Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)4ByteDance (Doubao)4Others24Total53Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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