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Growth differentiation factor-15 levels

PGPEP1 · rs888663

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,889 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.3 lower (95% confidence interval 0.24-0.36); p = 3 × 10⁻³².

How common The G allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 19, band 19p13.11 — between genes, 0.6 kb from GDF15.

What each result means

G/G Two copies of the version the research linked to Growth differentiation factor-15 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Growth differentiation factor-15 levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Growth differentiation factor-15 levels. This is the starting point the study compared everyone against.

Source

Clinical and genetic correlates of growth differentiation factor 15 in the community

Ho JE, Mahajan A, Chen MH, Larson MG, McCabe EL, Ghorbani A, Cheng S, Johnson AD, Lindgren CM, Kempf T, Lind L, Ingelsson E

and 5 more — show all

Vasan RS, Januzzi J, Wollert KC, Morris AP, Wang TJ

Clinical chemistry · 2012 · PMID 22997280

What people read about alongside this

Heart and circulation3 Blood sugar and insulin1 Cholesterol and blood fats1 Kidneys1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs888663

What is rs888663?

rs888663 is a single position in the genome, in or near the PGPEP1 gene. Published research associates it with growth differentiation factor-15 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs888663?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (3 papers), blood sugar and insulin (1 papers), cholesterol and blood fats (1 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs888663 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs888663 come from?

GWAS Catalog, Clin Chem 2012, PMID:22997280. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Growth differentiation factor-15 levels (rs888663). MyGeneLog™. https://www.mygenelog.com/variants/rs888663

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