Muscle fiber type ("sprinter gene")
ACTN3 · rs1815739
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What ClinVar records
Classification
Benign for Sprinting performance, ACTININ, ALPHA-3 POLYMORPHISM, Actn3 deficiency, INCREASED COLD TOLERANCE; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2025-02-16.
ClinVar record 18312 NM_001104.4(ACTN3):c.1729C>T (p.Arg577Ter)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
From our blog
Questions about rs1815739
What is rs1815739?
rs1815739 is a single position in the genome, in or near the ACTN3 gene. Published research associates it with muscle fiber type ("sprinter gene"). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs1815739?
Subjects that appear in the title or abstract of the same papers as this rsID include exercise and muscle (36 papers), running and endurance (35 papers), sport and performance (26 papers), natural selection (3 papers), longevity and ageing (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1815739 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1815739 come from?
Yang et al. 2003, American Journal of Human Genetics — ACTN3 genotype and elite athlete status. PMID 12879365. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
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Muscle fiber type ("sprinter gene") (rs1815739). MyGeneLog™. https://www.mygenelog.com/variants/rs1815739