The one axis here where a common variant can move a number a clinic already measures. Lipid levels are among the most heritable ordinary measurements in medicine — which is not the same as saying a genotype tells you what yours is.
Why this topic Statins are among the most prescribed drugs in the world and muscle symptoms are the commonest reason people stop them, which this site covers under SLCO1B1. The lipid numbers themselves are the other half of that conversation and they had no subject page.
Source: Willer et al., Nature Genetics 2013 — discovery and refinement of loci associated with lipid levels
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
FTO
Menarche (age at onset)
36 papers →APOA5
Triglyceride levels
30 papers →APOE
Lewy body disease
27 papers →SLCO1B1
Statin muscle-side-effect risk
21 papers →CETP
HDL cholesterol
15 papers →APOE
LDL cholesterol
14 papers →APOB
Cholesterol, total
12 papers →GCKR
Uric acid levels
10 papers →LPA
Parental lifespan (LPA, lipoprotein(a))
9 papers →FADS1
HDL cholesterol
9 papers →ALDH2
Alcohol flush reaction
9 papers →ZNF259
Triglyceride levels
9 papers →ABCA1
HDL cholesterol
8 papers →LDLR
Lipoprotein-associated phospholipase A2 activity and mass
8 papers →LPA
Coronary heart disease
7 papers →FADS1
Metabolite levels
6 papers →IL29
Chronic hepatitis C infection
6 papers →APOB
Triglycerides
5 papers →NCAN
LDL cholesterol
5 papers →MTHFR
Folate metabolism (MTHFR C677T)
5 papers →ABCA1
HDL cholesterol
5 papers →LDLR
Myocardial infarction (early onset)
4 papers →ADH1B
Alcohol metabolism speed
4 papers →MC4R
Waist circumference and related phenotypes
4 papers →AGER
Pulmonary function
4 papers →PCSK9
LDL cholesterol
4 papers →MLXIPL
Triglycerides
4 papers →GALNT2
HDL cholesterol
4 papers →CYP3A5
CYP3A5 expression (*3 allele)
4 papers →FTO
Obesity-related traits
4 papers →COBLL1
HDL cholesterol
3 papers →CELSR2
LDL cholesterol
3 papers →FTO
Obesity
3 papers →FTO
Obesity
3 papers →ZNF648
HDL cholesterol
3 papers →TBL2
Triglycerides
3 papers →FTH1
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
3 papers →FADS2
QT interval
3 papers →MTHFR
Folate metabolism (MTHFR A1298C)
3 papers →HPR
LDL cholesterol
3 papers →CYP7A1
Cholesterol, total
3 papers →FTH1
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
3 papers →APOC2
Triglycerides
3 papers →MCM6 / LCT
Lactose tolerance
3 papers →SCD
Metabolic traits
3 papers →FTO
Type 2 diabetes
3 papers →NCAN
LDL cholesterol
2 papers →CHRNA3
Smoking behavior
2 papers →LRP1
Triglycerides
2 papers →LCAT
HDL cholesterol
2 papers →CXCL12
Myocardial infarction (early onset)
2 papers →GCK
Glycated hemoglobin levels
2 papers →TGFB1
Colorectal cancer
2 papers →LIPC
Lipid traits
2 papers →GC
Vitamin D levels
2 papers →CETP
HDL cholesterol
2 papers →LPL
Metabolic syndrome
2 papers →TRPS1
Cholesterol, total
2 papers →TRIB1
Triglycerides
2 papers →LIPC
Triglycerides
2 papers →PCSK7
Cardiovascular disease risk factors
2 papers →ICAM1
Soluble ICAM-1
2 papers →DAB2IP
Abdominal aortic aneurysm
2 papers →DOCK6
HDL cholesterol
2 papers →LIPC
HDL cholesterol
1 paper →CPS1
Plasma homocysteine levels (post-methionine load test)
1 paper →INSIG2
LDL cholesterol
1 paper →TNFAIP3
Rheumatoid arthritis
1 paper →PGPEP1
Growth differentiation factor-15 levels
1 paper →KCNV2
Vascular endothelial growth factor levels
1 paper →LIPC
HDL cholesterol
1 paper →LPA
HDL cholesterol
1 paper →SCARB1
Lipoprotein-associated phospholipase A2 activity and mass
1 paper →GRK5
Type 2 diabetes
1 paper →NT5C2
Systolic blood pressure
1 paper →PLCL1
Low high density lipoprotein cholesterol levels
1 paper →TOMM40
C-reactive protein
1 paper →HNF1A
C-reactive protein levels
1 paper →DOCK7
Triglycerides
1 paper →SHBG
Testosterone levels
1 paper →MYL2
Alcohol consumption
1 paper →APOA5
Carotenoid and tocopherol levels
1 paper →GPRC5B
Obesity
1 paper →PHACTR1
Coronary heart disease
1 paper →LPL
Triglycerides
1 paper →COBLL1
Waist-hip ratio
1 paper →NLRC5
HDL cholesterol
1 paper →SLC2A9
Urate levels
1 paper →CETP
HDL Cholesterol - Triglycerides (HDLC-TG)
1 paper →HFE
Iron overload risk (HFE H63D)
1 paper →HFE
Iron overload risk (hereditary hemochromatosis)
1 paper →HNF4A
C-reactive protein levels
1 paper →LEPR
C-reactive protein
1 paper →ADIPOQ
Adiponectin levels
1 paper →GPR146
Cholesterol, total
1 paper →ACADS
Metabolite levels
1 paper →LHX2
Waist circumference
1 paper →APOE
Alzheimer's disease (late onset)
1 paper →DOCK7
Triglycerides
1 paper →SLC18A1
Triglycerides
1 paper →CAV1
PR interval
1 paper →NOS2
Psoriasis
1 paper →HNF4A
Type 2 diabetes
1 paper →EDN1
Circulating vasoactive peptide levels
1 paper →G6PC2
Fasting plasma glucose
1 paper →ABO
Soluble E-selectin levels
1 paper →FUT2
Pediatric autoimmune diseases
1 paper →FURIN / FES
Parental lifespan (FURIN/FES)
1 paper →FURIN
Trauma exposure
1 paper →PCSK1
Proinsulin levels
1 paper →BDNF
Smoking behavior
1 paper →FTO
Body mass index
1 paper →WDR12
Myocardial infarction (early onset)
1 paper →RREB1
Waist-hip ratio
1 paper →AUTS2
Alcohol consumption
1 paper →ZFPM2
Vascular endothelial growth factor levels
1 paper →ABCA1
Low high density lipoprotein cholesterol levels
1 paper →HMGCR
LDL cholesterol
1 paper →PLG
Lp (a) levels
1 paper →CFH
Circulating myeloperoxidase levels (serum)
1 paper →RHOU
Basal cell carcinoma
1 paper →FLJ45244
Response to statin therapy
1 paper →ABO
ABO blood type
1 paper →PON-1
Paraoxonase activity
1 paper →PGPEP1
Growth differentiation factor-15 levels
1 paper →NKX2-1
Thyroid cancer
1 paper →VKORC1
Warfarin sensitivity
1 paper →Europe PMC, title and abstract only, searched for “LDL cholesterol”, “HDL cholesterol”, “blood lipids”, “hypercholesterolemia” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.