LEPR · rs1805096
Where this position leads
Condition: C-Reactive Protein Levels
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 8,280 African American female individuals, 3,548 Hispanic female individuals; replicated in 3,787 African American female individuals, 3,548 Hispanic female individuals, 5,656 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.113 lower (95% confidence interval 0.064-0.162); p = 2 × 10−9.
How common The A allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 1, band 1p31.3 — a synonymous change in LEPR.
What ClinVar records
Classification
Benign for Obesity due to leptin receptor gene deficiency; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 9 submitters), last evaluated 2026-02-04.
ClinVar record 298000 NM_002303.6(LEPR):c.3057G>A (p.Pro1019=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs1805096 is a single position in the genome, in or near the LEPR gene. Published research associates it with c-reactive protein. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (3 papers), exercise and muscle (3 papers), bones and fractures (1 papers), cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Am J Hum Genet 2012, PMID:22939635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein (rs1805096). MyGeneLog™. https://www.mygenelog.com/variants/rs1805096