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Glycated hemoglobin levels

GCK · rs1799884

Where this position leads

Condition: Type 2 Diabetes

rs1799884 Condition: Type 2 Diabetes Type 2 Diabetes Condition Topic: Blood sugar and insulin Blood sugar and insulin Topic rs1799884 rs1799884 GCK

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied up to 46,368 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.04 % higher (95% confidence interval 0.03-0.05); p = 1 × 10−20.

How common The T allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 7, band 7p13 — inside GCK.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-06-28. ClinVar record 1258742 NC_000007.14:g.44189469C>T

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Glycated hemoglobin levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Glycated hemoglobin levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Glycated hemoglobin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1799884

What is rs1799884?

rs1799884 is a single position in the genome, in or near the GCK gene. Published research associates it with glycated hemoglobin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1799884 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1799884?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (27 papers), cholesterol and blood fats (2 papers), exercise and muscle (1 papers), natural selection (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1799884 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1799884 come from?

GWAS Catalog, Diabetes 2010, PMID:20858683. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Glycated hemoglobin levels (rs1799884). MyGeneLog™. https://www.mygenelog.com/variants/rs1799884

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