Sensitive

Type 2 diabetes

GRK5 · rs10886471

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,839 Han Chinese ancestry cases, 1,873 Han Chinese ancestry controls; replicated in 15,979 East Asian ancestry cases, 19,360 East Asian ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 159 Filipino ancestry cases, 1,624 Filipino ancestry controls.

The effect Each copy of the C allele carried 1.12 times the odds of Type 2 diabetes (95% confidence interval 1.08-1.16); p = 7 × 10⁻⁹.

How common The C allele had a frequency of about 78% in the people studied.

Where it sits Chromosome 10, band 10q26.11 — in an intron of GRK5.

What each result means

C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.

T/T No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.

Source

A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans

Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L

and 26 more — show all

Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, Guo K, Zuo X, Guo X, Yang H, Zhou X, Zhang X, Qi L, Loos RJ, Hu FB, Wu T, Liu Y, Liu L, Yang Z, Hu R, Jia W, Ji L, Li Y, Lin X

DIAGRAM Consortium · AGEN-T2D Consortium

Diabetes · 2013 · PMID 22961080 · open access

What people read about alongside this

Blood sugar and insulin8 Cholesterol and blood fats1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10886471

What is rs10886471?

rs10886471 is a single position in the genome, in or near the GRK5 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10886471 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10886471?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (8 papers), cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10886471 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10886471 come from?

GWAS Catalog, Diabetes 2012, PMID:22961080. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs10886471). MyGeneLog™. https://www.mygenelog.com/variants/rs10886471

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