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Who was studied 397 European ancestry cases, 1,211 controls; replicated in 1,408 cases, 2,426 controls, 875 European ancestry cases, 832 European ancestry controls.
The effect
Each copy of the C allele carried 1.33 times the odds of Rheumatoid arthritis (95% confidence interval 1.15-1.52); p = 1 × 10−9.
How common The C allele had a frequency of about 71% in the people studied.
Where it sits Chromosome 6, band 6q23.3 — in an intron of LINC03004.
What each result means
C/CTwo copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10499194
What is rs10499194?
rs10499194 is a single position in the genome, in or near the TNFAIP3 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10499194 linked to?
On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10499194?
Subjects that appear in the title or abstract of the same papers as this rsID include allergies (1 papers), blood sugar and insulin (1 papers), cholesterol and blood fats (1 papers), liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10499194 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10499194 come from?
GWAS Catalog, Nat Genet 2007, PMID:17982456. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 5232166222226Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity6Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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