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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls; replicated in 65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls.
The effect
Each copy of the C allele carried 1.45 times the odds of Obesity; p = 6 × 10−39.
How common The C allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 16, band 16q12.2 — in an intron of FTO.
What ClinVar records
Classificationrisk factor for OBESITY (BMIQ14), SUSCEPTIBILITY TO; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2015-09-03.
ClinVar record 217824NM_001080432.3(FTO):c.46-43098T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Obesity. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Obesity. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Obesity. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
In the news
MyGeneLog™
2026-03-06 · Haapaniemi H et al. The genetic basis of dermatophytosis skin infection susceptibility. Nature Communications 2026, PMID:41792138
Dermatophytosis — the fungal infection behind athlete's foot, nail fungus and ringworm — affects around 20% of the world's population. A genome-wide meta-analysis of over 250,000 cases from FinnGen, the Estonian Biobank, UK Biobank and the Million Veteran Program found 30 genome-wide significant loci, with top signals near ZNF646, HLA-DQB1, FLG, FTO, SLURP2 and KRT77, and pointed to keratin biology, the skin barrier, immune function and obesity. 19 of the study's positions already have pages here, including rs1421085 in FTO, the best-known obesity position, and five on the dermatophytosis page. PMID:41792138.
rs1421085 is a single position in the genome, in or near the FTO gene. Published research associates it with obesity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1421085 linked to?
On MyGeneLog this position is linked to Obesity and Body Weight, Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs1421085?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (25 papers), exercise and muscle (15 papers), sleep and insomnia (5 papers), depression and stress (4 papers), bones and fractures (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1421085 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1421085 come from?
GWAS Catalog, Nat Genet 2013, PMID:23563607. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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