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C-reactive protein

TOMM40 · rs1160985

Where this position leads

What the study found

Who was studied 8,280 African American female individuals, 3,548 Hispanic female individuals; replicated in 3,787 African American female individuals, 3,548 Hispanic female individuals, 5,656 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.134 lower; p = 4 × 10⁻¹³.

How common The C allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 19, band 19q13.32 — in an intron of TOMM40.

What each result means

C/C Two copies of the version the research linked to C-reactive protein. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to C-reactive protein. That is a smaller link than two copies.

T/T No copy of the version the research linked to C-reactive protein. This is the starting point the study compared everyone against.

Source

Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women

Reiner AP, Beleza S, Franceschini N, Auer PL, Robinson JG, Kooperberg C, Peters U, Tang H

American journal of human genetics · 2012 · PMID 22939635

What people read about alongside this

Cholesterol and blood fats1 Longevity and ageing1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1160985

What is rs1160985?

rs1160985 is a single position in the genome, in or near the TOMM40 gene. Published research associates it with c-reactive protein. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1160985 linked to?

On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1160985?

Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (1 papers), longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1160985 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1160985 come from?

GWAS Catalog, Am J Hum Genet 2012, PMID:22939635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

C-reactive protein (rs1160985). MyGeneLog™. https://www.mygenelog.com/variants/rs1160985

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