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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 10,701 European ancestry individuals; replicated in 16,378 European ancestry individuals.
The effect
The reported allele is G; the catalogue records no effect size
; p = 1 × 10−26.
How common The G allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 5, band 5q15 — a missense change in CAST.
What ClinVar records
ClassificationBenign/Likely benign for Obesity due to prohormone convertase I deficiency, Early onset severe obesity; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 10 submitters), last evaluated 2026-02-04.
ClinVar record 354639NM_000439.5(PCSK1):c.2069G>C (p.Ser690Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Proinsulin levels. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Proinsulin levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Proinsulin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs6235
What is rs6235?
rs6235 is a single position in the genome, in or near the PCSK1 gene. Published research associates it with proinsulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs6235?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (8 papers), cholesterol and blood fats (1 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs6235 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6235 come from?
GWAS Catalog, Diabetes 2011, PMID:21873549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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