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Carotenoid and tocopherol levels

APOA5 · rs12272004

Where this position leads

Condition: High Triglycerides

Supplement: Beta-carotene and vitamin E

rs12272004 Condition: High Triglycerides High Triglycerides Condition Supplement: Beta-carotene and vitamin E Beta-carotene and vitamin E Supplement rs12272004 rs12272004 APOA5

What the study found

Who was studied 1,191 European ancestry individuals; replicated in 2,540 European ancestry individuals, 211 individuals.

The effect Each copy of the A allele shifted the measure 0.07 umol/L higher (95% confidence interval 0.049-0.095); p = 8 × 10−10.

How common The A allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 11, band 11q23.3 — between genes, 15.2 kb from BUD13.

What each result means

A/A Two copies of the version the research linked to Carotenoid and tocopherol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Carotenoid and tocopherol levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to Carotenoid and tocopherol levels. This is the starting point the study compared everyone against.
Source
Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
Ferrucci L, Perry JR, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, Fried LP, Albanes D
and 9 more — show all
Corsi AM, Cherubini A, Guralnik J, Bandinelli S, Singleton A, Virtamo J, Walston J, Semba RD, Frayling TM
American journal of human genetics · 2009 · PMID 19185284

What people read about alongside this

Vitamins and nutrient levels1 Cholesterol and blood fats1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs12272004

What is rs12272004?

rs12272004 is a single position in the genome, in or near the APOA5 gene. Published research associates it with carotenoid and tocopherol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12272004 linked to?

On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs12272004?

Subjects that appear in the title or abstract of the same papers as this rsID include vitamins and nutrient levels (1 papers), cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs12272004 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12272004 come from?

GWAS Catalog, Am J Hum Genet 2009, PMID:19185284. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Carotenoid and tocopherol levels (rs12272004). MyGeneLog™. https://www.mygenelog.com/variants/rs12272004

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