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Waist-hip ratio

RREB1 · rs6931262

Where this position leads

Condition: Waist-to-Hip Ratio (Body Fat Distribution)

What the study found

Who was studied up to 19,744 African American individuals; replicated in Up to 7,606 African American individuals.

The effect Each copy of the T allele shifted the measure 0.06 higher (95% confidence interval 0.04-0.08); p = 3 × 10⁻⁸.

How common The T allele had a frequency of about 25% in the people studied.

Where it sits Chromosome 6, band 6p24.3 — in an intron of RREB1.

What each result means

C/C No copy of the version the research linked to Waist-hip ratio. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Waist-hip ratio. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Waist-hip ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association of body fat distribution in African ancestry populations suggests new loci

Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR

and 81 more — show all

Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS

PLoS genetics · 2013 · PMID 23966867 · open access

What people read about alongside this

Cholesterol and blood fats1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs6931262

What is rs6931262?

rs6931262 is a single position in the genome, in or near the RREB1 gene. Published research associates it with waist-hip ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6931262 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs6931262?

Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs6931262 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6931262 come from?

GWAS Catalog, PLoS Genet 2013, PMID:23966867. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Waist-hip ratio (rs6931262). MyGeneLog™. https://www.mygenelog.com/variants/rs6931262

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