3 4823415122226Reads by AI crawlersClaude2ChatGPT3Google · Gemini4Perplexity1Meta AI5Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
G/GNeither copy carries the associated allele. FURIN is an enzyme that cuts other proteins into their working form, including ones in the blood-pressure pathway. This locus is an established blood-pressure signal. On its own this tells one person almost nothing: the effect is a small shift in a population average, and how long anyone lives is mostly not genetic at all.
G/TOne copy of the associated allele. About 47% in Europe, 87% in Africa, 16% in East Asia. What was measured is a difference in average parental lifespan across half a million families — months, not years, and invisible in any one family.
T/TTwo copies. Still a shift in an average rather than a fact about a life. The reason to record it is what it points at biologically, not what it predicts.
This is an association with how long a population lives, not a prediction about one person. Nothing here is used clinically, nothing here is a reason to take anything, and no genotype at this position changes what anyone should do.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs6224
What is rs6224?
rs6224 is a single position in the genome, in or near the FURIN / FES gene. Published research associates it with parental lifespan (furin/fes). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6224 linked to?
On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs6224?
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs6224 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6224 come from?
Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 1e-10. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 4823415122226Reads by AI crawlersClaude2ChatGPT3Google · Gemini4Perplexity1Meta AI5Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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