Standard

LDL cholesterol

HMGCR · rs7703051

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs7703051 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs7703051 rs7703051 HMGCR

What the study found

Who was studied 2,346 Micronesian ancestry individuals.

The effect Each copy of the A allele shifted the measure 18 % s.d. higher; p = 1 × 10−8.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 5, band 5q13.3 — between genes, 6.7 kb from HMGCR.

What each result means

A/A Two copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
C/C No copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs7703051

What is rs7703051?

rs7703051 is a single position in the genome, in or near the HMGCR gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7703051 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs7703051?

Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs7703051 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7703051 come from?

GWAS Catalog, Arterioscler Thromb Vasc Biol 2008, PMID:18802019. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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LDL cholesterol (rs7703051). MyGeneLog™. https://www.mygenelog.com/variants/rs7703051

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