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Response to statin therapy

FLJ45244 · rs8014194

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs8014194 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs8014194 rs8014194 FLJ45244

What the study found

Who was studied 3,928 European ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−8.

How common The A allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 14, band 14q32.13 — in an intron of CLMN.

What each result means

A/A Two copies of the version the research linked to Response to statin therapy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Response to statin therapy. That is a smaller link than two copies.
T/T No copy of the version the research linked to Response to statin therapy. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs8014194

What is rs8014194?

rs8014194 is a single position in the genome, in or near the FLJ45244 gene. Published research associates it with response to statin therapy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8014194 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs8014194?

Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs8014194 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8014194 come from?

GWAS Catalog, PLoS One 2010, PMID:20339536. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Response to statin therapy (rs8014194). MyGeneLog™. https://www.mygenelog.com/variants/rs8014194

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