NKX2-1 · rs944289
Where this position leads
Condition: Thyroid Cancer
Strength of the evidence
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 192 European ancestry cases, 37,196 European ancestry controls; replicated in 432 European ancestry cases, 1,727 European ancestry controls.
The effect Each copy of the T allele carried 1.37 times the odds of Thyroid cancer (95% confidence interval 1.24-1.52); p = 2 × 10−9.
How common The T allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 14, band 14q13.3 — in an intron of LINC00609.
How common each version is
CT
C 54.2% · T 45.8%
C 55.8% · T 44.2%
C 55.5% · T 44.5%
C 56.9% · T 43.1%
C 59.8% · T 40.2%
C 54.6% · T 45.4%
C 60.7% · T 39.3%
C 57.8% · T 42.2%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs944289 is a single position in the genome, in or near the NKX2-1 gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), cholesterol and blood fats (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2009, PMID:19198613. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs944289). MyGeneLog™. https://www.mygenelog.com/variants/rs944289