Whether an infection passes or stays is decided as much by the host as by the microbe — and the host genes that decide it are usually the ones that show the immune system what it is fighting.
Why this topic Five years of everyone having an opinion about immunity, and the durable part of it is old: HLA, and why two people meet the same virus and do not get the same illness.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
IL29
Chronic hepatitis C infection
100 papers →HLA-DPA1
Hepatitis B
60 papers →HLA-DPB1
Hepatitis B (viral clearance)
55 papers →ITPA
Chronic hepatitis C infection
35 papers →UBE4B
Hepatocellular carcinoma
11 papers →TGFB1
Colorectal cancer
9 papers →HLA-DQA2
Crohn's disease
8 papers →HLA-C
Hepatitis B
6 papers →MERTK
Hepatitis C induced liver fibrosis
6 papers →ALDH2
Alcohol flush reaction
6 papers →HLA-DQB1
Follicular lymphoma
5 papers →MTHFR
Folate metabolism (MTHFR C677T)
5 papers →GC
Vitamin D levels
5 papers →PARVB
Hematological and biochemical traits
4 papers →SCARB1
Lipoprotein-associated phospholipase A2 activity and mass
3 papers →HLA-DQA2
Knee osteoarthritis
3 papers →DARC
Monocyte chemoattractant protein-1 levels
3 papers →ATG16L1
Crohn's disease
3 papers →C6orf10
Ulcerative colitis
3 papers →TERT
Lung adenocarcinoma
3 papers →IL7R
Ulcerative colitis
3 papers →CCR5
HIV-1 resistance (CCR5-delta32)
3 papers →STAT4
Type 1 diabetes
3 papers →HLA-DPA3
Chronic hepatitis B infection
3 papers →IL23R
Crohn's disease
2 papers →STAT4
Systemic lupus erythematosus
2 papers →ADH1B
Alcohol metabolism speed
2 papers →RNF7
Hepatitis C induced liver fibrosis
2 papers →MTHFR
Folate metabolism (MTHFR A1298C)
2 papers →IFIH1
Type 1 diabetes
2 papers →near FAP
Ulcerative colitis
2 papers →IFIH1
Psoriasis
2 papers →Unknown
Crohn's disease
2 papers →SLCO1B1
Statin muscle-side-effect risk
2 papers →PRDM1
Systemic lupus erythematosus
2 papers →TERT
Breast cancer
1 paper →APOB
Triglycerides
1 paper →TNPO
Systemic sclerosis
1 paper →STAT6
Allergic sensitization
1 paper →LAMC1
Colorectal cancer
1 paper →SCARB1
Vitamin E levels
1 paper →PRKD2
Chronic lymphocytic leukemia
1 paper →GNL3
Osteoarthritis
1 paper →ATM
Response to metformin in type 2 diabetes (glycemic)
1 paper →HLA-DRB1
Skin and soft tissue Staphylococcus aureus infection
1 paper →KIR2DL1
Inflammatory bowel disease
1 paper →GRIN2A
Hepatitis B
1 paper →SLC16A9
Uric acid levels
1 paper →near POU5F1B
Prostate cancer
1 paper →CETP
HDL Cholesterol - Triglycerides (HDLC-TG)
1 paper →HNF4A
C-reactive protein levels
1 paper →ABCA1
HDL cholesterol
1 paper →HPR
LDL cholesterol
1 paper →near PPT2
Serum total protein levels
1 paper →TNIP1
Systemic sclerosis
1 paper →TERT
Prostate cancer
1 paper →PLCE1
Esophageal cancer
1 paper →HLA-B
HIV-1 control
1 paper →HLA-C
Hypothyroidism
1 paper →FTH1
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
1 paper →C4
Complement C3 and C4 levels
1 paper →HLA-DQA2
Narcolepsy
1 paper →HLA-DRB
Complement C3 and C4 levels
1 paper →CETP
HDL cholesterol
1 paper →CAV1
PR interval
1 paper →NADSYN1
Vitamin D levels
1 paper →NOTCH4
Colorectal cancer
1 paper →TP63
Lung cancer
1 paper →LY75
Idiopathic membranous nephropathy
1 paper →BDNF
Smoking behavior
1 paper →IL12A
Primary biliary cholangitis
1 paper →LDLR
Lipoprotein-associated phospholipase A2 activity and mass
1 paper →HLA-DQB1
Allergic sensitization
1 paper →POU5F1B
Prostate cancer
1 paper →GRAMD1B
Chronic lymphocytic leukemia
1 paper →HLA-DQA2
Crohn's disease
1 paper →PSORS1C1
Crohn's disease
1 paper →FTO
Menarche (age at onset)
1 paper →Europe PMC, title and abstract only, searched for “hepatitis B”, “hepatitis C”, “viral clearance”, “HLA class II” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.