IFIH1 · rs1990760
Where this position leads
Condition: Type 1 Diabetes
What the study found
Who was studied 8,506 European ancestry cases, up to 10,596 European ancestry controls.
The effect Each copy of the C allele carried 1.20 times the odds of Type 1 diabetes; p = 2 × 10−14.
Where it sits Chromosome 2, band 2q24.2 — a missense change in IFIH1.
What ClinVar records
Classification
Benign/Likely benign for Singleton-Merten syndrome 1, Aicardi-Goutieres syndrome 7; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 9 submitters), last evaluated 2026-02-04.
ClinVar record 261566 NM_022168.4(IFIH1):c.2836G>A (p.Ala946Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs1990760 is a single position in the genome, in or near the IFIH1 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers), gut and food intolerance (2 papers), infection and immunity (2 papers), bones and fractures (1 papers), liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, PLoS Genet 2011, PMID:21829393. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs1990760). MyGeneLog™. https://www.mygenelog.com/variants/rs1990760