Sensitive

Esophageal cancer

PLCE1 · rs2274223

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Esophageal cancer — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2011, PMID:21642993)
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Esophageal cancer. (GWAS Catalog, Nat Genet 2011, PMID:21642993)
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Esophageal cancer compared to the general population. (GWAS Catalog, Nat Genet 2011, PMID:21642993)

Source: GWAS Catalog, Nat Genet 2011, PMID:21642993

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2274223

What is rs2274223?

rs2274223 is a single position in the genome, in or near the PLCE1 gene. Published research associates it with esophageal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs2274223?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2274223 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2274223 come from?

GWAS Catalog, Nat Genet 2011, PMID:21642993. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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