PLCE1 · rs2274223
Where this position leads
Condition: Oesophageal Cancer
What the study found
Who was studied 2,031 Han Chinese ancestry cases, 2,044 Han Chinese ancestry controls; replicated in 3,986 Han Chinese ancestry cases, 4,157 Han Chinese ancestry controls.
The effect Each copy of the G allele carried 1.34 times the odds of Esophageal cancer (95% confidence interval 1.26-1.42); p = 4 × 10−20.
How common The G allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 10, band 10q23.33 — a missense change in PLCE1.
What ClinVar records
Classification
Benign for Nephrotic syndrome, type 3, Focal segmental glomerulosclerosis; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 13 submitters), last evaluated 2026-02-01.
ClinVar record 260728 NM_016341.4(PLCE1):c.5780A>G (p.His1927Arg)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs2274223 is a single position in the genome, in or near the PLCE1 gene. Published research associates it with esophageal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Oesophageal Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include alcohol and the flush (1 papers), infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2011, PMID:21642993. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Esophageal cancer (rs2274223). MyGeneLog™. https://www.mygenelog.com/variants/rs2274223