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Hepatitis C induced liver fibrosis

RNF7 · rs16851720

Where this position leads

Condition: Chronic Hepatitis C

rs16851720 Condition: Chronic Hepatitis C Chronic Hepatitis C Condition Topic: Liver Liver Topic rs16851720 rs16851720 RNF7

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,161 European ancestry HCV-infected individuals; replicated in 1,181 European ancestry HCV-infected individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 9 × 10−9.

How common The C allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 3, band 3q23 — in an intron of RNF7.

What each result means

A/A No copy of the version the research linked to Hepatitis C induced liver fibrosis. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Hepatitis C induced liver fibrosis. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Hepatitis C induced liver fibrosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs16851720

What is rs16851720?

rs16851720 is a single position in the genome, in or near the RNF7 gene. Published research associates it with hepatitis c induced liver fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16851720 linked to?

On MyGeneLog this position is linked to Chronic Hepatitis C. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs16851720?

Subjects that appear in the title or abstract of the same papers as this rsID include liver (3 papers), infection and immunity (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs16851720 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16851720 come from?

GWAS Catalog, Gastroenterology 2012, PMID:22841784. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hepatitis C induced liver fibrosis (rs16851720). MyGeneLog™. https://www.mygenelog.com/variants/rs16851720

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