3 5253324222227Reads by AI crawlersClaude5ChatGPT3Google · Gemini3Perplexity2Meta AI4Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 7,410 European ancestry cases, 11,009 European ancestry controls; replicated in 7,473 European ancestry cases, 42,938 European ancestry controls.
The effect
Each copy of the A allele carried 1.09 times the odds of Osteoarthritis (95% confidence interval 1.06-1.12); p = 5 × 10−9.
How common The A allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 3, band 3p21.1 — a missense change in GNL3.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Osteoarthritis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Osteoarthritis. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs11177
What is rs11177?
rs11177 is a single position in the genome, in or near the GNL3 gene. Published research associates it with osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11177 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs11177?
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs11177 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11177 come from?
GWAS Catalog, Lancet 2012, PMID:22763110. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 5253324222227Reads by AI crawlersClaude5ChatGPT3Google · Gemini3Perplexity2Meta AI4Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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