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Who was studied 505 European ancestry cases, 1,438 European ancestry controls; replicated in 1,024 European ancestry cases, 1,677 European ancestry controls.
The effect
Each copy of the A allele carried 1.45 times the odds of Chronic lymphocytic leukemia (95% confidence interval 1.31-1.61); p = 4 × 10−12.
How common The A allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 11, band 11q24.1 — in an intron of GRAMD1B.
What each result means
A/ATwo copies of the version the research linked to Chronic lymphocytic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Chronic lymphocytic leukemia. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Chronic lymphocytic leukemia. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs735665
What is rs735665?
rs735665 is a single position in the genome, in or near the GRAMD1B gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs735665 linked to?
On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs735665?
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs735665 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs735665 come from?
GWAS Catalog, Nat Genet 2008, PMID:18758461. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 5062116223225Reads by AI crawlersClaude6ChatGPT2Google · Gemini1Perplexity1Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others25Total50Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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