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Narcolepsy

HLA-DQA2 · rs2858884

Where this position leads

Condition: Narcolepsy

rs2858884 Condition: Narcolepsy Narcolepsy Condition rs2858884 rs2858884 HLA-DQA2

What the study found

Who was studied 562 European ancestry cases, 702 European ancestry controls; replicated in 370 cases, 495 controls.

The effect Each copy of the A allele carried 1.79 times the odds of Narcolepsy (95% confidence interval 1.45-2.17); p = 3 × 10−8.

How common The A allele had a frequency of about 81% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 0.6 kb from HLA-DQB3.

What each result means

A/A Two copies of the version the research linked to Narcolepsy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Narcolepsy. That is a smaller link than two copies.
C/C No copy of the version the research linked to Narcolepsy. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2858884

What is rs2858884?

rs2858884 is a single position in the genome, in or near the HLA-DQA2 gene. Published research associates it with narcolepsy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2858884 linked to?

On MyGeneLog this position is linked to Narcolepsy. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs2858884?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2858884 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2858884 come from?

GWAS Catalog, Nat Genet 2010, PMID:20711174. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Narcolepsy (rs2858884). MyGeneLog™. https://www.mygenelog.com/variants/rs2858884

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