DARC · rs12075
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 815 Hispanic children.
The effect The reported allele is A; the catalogue records no effect size ; p = 1 × 10−21.
How common The A allele had a frequency of about 43% in the people studied.
Where it sits Chromosome 1, band 1q23.2 — a missense change in ACKR1.
What ClinVar records
Classification
Benign for DUFFY BLOOD GROUP SYSTEM, FYA/FYB POLYMORPHISM, ACKR1-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2016-05-27.
ClinVar record 17728 NM_002036.4(ACKR1):c.125G>A (p.Gly42Asp)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs12075 is a single position in the genome, in or near the DARC gene. Published research associates it with monocyte chemoattractant protein-1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (3 papers), liver (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Cytokine 2012, PMID:23017229. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Monocyte chemoattractant protein-1 levels (rs12075). MyGeneLog™. https://www.mygenelog.com/variants/rs12075