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Complement C3 and C4 levels

HLA-DRB · rs3763317

Where this position leads

Condition: Complement C3 and C4 Levels

rs3763317 Condition: Complement C3 and C4 Levels Complement C3 and C4 Levels Condition rs3763317 rs3763317 HLA-DRB

What the study found

Who was studied 1,999 Han Chinese ancestry male individuals; replicated in 1,496 Han Chinese ancestry male individuals.

The effect Each copy of the C allele shifted the measure 0.12 g/L higher (95% confidence interval 0.10-0.14); p = 9 × 10−66.

How common The C allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 1.2 kb from TSBP1-AS1.

What each result means

C/C Two copies of the version the research linked to Complement C3 and C4 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Complement C3 and C4 levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Complement C3 and C4 levels. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3763317

What is rs3763317?

rs3763317 is a single position in the genome, in or near the HLA-DRB gene. Published research associates it with complement c3 and c4 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3763317 linked to?

On MyGeneLog this position is linked to Complement C3 and C4 Levels. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3763317?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3763317 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3763317 come from?

GWAS Catalog, PLoS Genet 2012, PMID:23028341. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Complement C3 and C4 levels (rs3763317). MyGeneLog™. https://www.mygenelog.com/variants/rs3763317

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