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Hepatitis B (viral clearance)

HLA-DPB1 · rs9277535

Where this position leads

Condition: Chronic Hepatitis B

rs9277535 Condition: Chronic Hepatitis B Chronic Hepatitis B Condition Topic: Infection and immunity Infection and immunity Topic Topic: Liver Liver Topic rs9277535 rs9277535 HLA-DPB1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 181 East Asian ancestry HBV carriers, 184 East Asian ancestry controls, 185 East Asian ancestry spontaneously HBV-resolved individuals; replicated in Up to 8,045 East Asian ancestry HBV carriers, up to 9,003 East Asian ancestry controls, up to 3,995 East Asian ancestry spontaneously HBV-resolved individuals.

The effect Each copy of the G allele carried 1.52 times the odds of Hepatitis B (viral clearance) (95% confidence interval 1.37-1.67); p = 2 × 10−17.

How common The G allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in the 3′ untranslated region of HLA-DPB1.

What each result means

A/A No copy of the version the research linked to Hepatitis B (viral clearance). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Hepatitis B (viral clearance). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Hepatitis B (viral clearance). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs9277535

What is rs9277535?

rs9277535 is a single position in the genome, in or near the HLA-DPB1 gene. Published research associates it with hepatitis b (viral clearance). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9277535 linked to?

On MyGeneLog this position is linked to Chronic Hepatitis B. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs9277535?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (55 papers), liver (13 papers), alcohol and the flush (1 papers), blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs9277535 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9277535 come from?

GWAS Catalog, PLoS One 2012, PMID:22737229. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hepatitis B (viral clearance) (rs9277535). MyGeneLog™. https://www.mygenelog.com/variants/rs9277535

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