4 4512224222226Reads by AI crawlersClaude1ChatGPT2Google · Gemini2Perplexity2Meta AI4Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total45Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,296 European ancestry cases, 5,171 European ancestry controls; replicated in 2,753 European ancestry cases, 4,569 European ancestry controls.
The effect
Each copy of the C allele carried 1.50 times the odds of Systemic sclerosis (95% confidence interval 1.35-1.67); p = 2 × 10−13.
Where it sits Chromosome 7, band 7q32.1 — between genes, 0.1 kb from TNPO3.
What each result means
C/CTwo copies of the version the research linked to Systemic sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Systemic sclerosis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Systemic sclerosis. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10488631
What is rs10488631?
rs10488631 is a single position in the genome, in or near the TNPO gene. Published research associates it with systemic sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10488631 linked to?
On MyGeneLog this position is linked to Systemic Sclerosis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10488631?
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers), liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10488631 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10488631 come from?
GWAS Catalog, Nat Genet 2010, PMID:20383147. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 4512224222226Reads by AI crawlersClaude1ChatGPT2Google · Gemini2Perplexity2Meta AI4Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total45Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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