TERT · rs10069690
Where this position leads
Condition: Breast Cancer
What the study found
Who was studied 1,004 African American cases, 2,745 African American controls, 1,718 European ancestry cases, 3,670 European ancestry controls; replicated in 2,292 European ancestry cases, 16,901 European ancestry controls.
The effect Each copy of the T allele carried 1.18 times the odds of Breast cancer (95% confidence interval 1.13-1.25); p = 1 × 10−10.
How common The T allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 5, band 5p15.33 — in an intron of TERT.
What ClinVar records
Classification
Benign for Chronic osteomyelitis, Dyskeratosis congenita, autosomal dominant 2, Idiopathic Pulmonary Fibrosis; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-01-26.
ClinVar record 225783 NM_198253.3(TERT):c.1951-205G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
2026-07-10 · Jee YH, et al. Nature Communications 2026, PMID:42431967
Genetic drivers of etiologic heterogeneity in thyroid cancer
Newly curated by the GWAS Catalog: 66 associations across 1 trait ("Thyroid cancer"), from Jee YH, et al. in Nature Communications, 2026. The catalogue records its sample as 10,717 cases and 1,262,106 controls. This site already has 22 of its 66 positions — 13 on the Thyroid Cancer page; 2 on the Ovarian Cancer page; 2 on the Blood Cell Counts page — including rs4733129 (NRG1), rs116909374 (MBIP), rs10069690 (TERT). Everything above is from the catalogue's records, assembled by code; the paper itself is linked. PMID:42431967.
rs10069690 is a single position in the genome, in or near the TERT gene. Published research associates it with breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include fertility (1 papers), infection and immunity (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2011, PMID:22037553. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Breast cancer (rs10069690). MyGeneLog™. https://www.mygenelog.com/variants/rs10069690