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Hepatitis B

GRIN2A · rs11866328

Where this position leads

What the study found

Who was studied 1,944 Han Chinese ancestry progressed cases, 854 Han Chinese ancestry asymptomatic carriers.

The effect Each copy of the G allele carried 1.68 times the odds of Hepatitis B (95% confidence interval 1.40-2.02); p = 2 × 10⁻⁸.

Where it sits Chromosome 16, band 16p13.2 — in an intron of GRIN2A.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-06-14. ClinVar record 681804 NM_001134407.3(GRIN2A):c.2595+152C>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G Two copies of the version the research linked to Hepatitis B. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Hepatitis B. That is a smaller link than two copies.

T/T No copy of the version the research linked to Hepatitis B. This is the starting point the study compared everyone against.

Source

A genome-wide association study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that affects disease progression of chronic HBV infection

Liu L, Li J, Yao J, Yu J, Zhang J, Ning Q, Wen Z, Yang D, He Y, Kong X, Song Q, Chen M

and 4 more — show all

Yang H, Liu Q, Li S, Lin J

Viral immunology · 2011 · PMID 22004137

What people read about alongside this

Infection and immunity1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs11866328

What is rs11866328?

rs11866328 is a single position in the genome, in or near the GRIN2A gene. Published research associates it with hepatitis b. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11866328 linked to?

On MyGeneLog this position is linked to Chronic Hepatitis B. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs11866328?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs11866328 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11866328 come from?

GWAS Catalog, Viral Immunol 2011, PMID:22004137. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hepatitis B (rs11866328). MyGeneLog™. https://www.mygenelog.com/variants/rs11866328

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