Sensitive

Knee osteoarthritis

HLA-DQA2 · rs10947262

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 899 Japanese ancestry cases, 3,396 Japanese ancestry controls; replicated in 167 Japanese ancestry cases, 347 Japanese ancestry controls, 813 European ancestry cases, 1,071 European ancestry controls,.

The effect Each copy of the T allele carried 1.31 times the odds of Knee osteoarthritis (95% confidence interval 1.20-1.44); p = 5 × 10⁻⁹.

How common The T allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in a non-coding transcript of BTNL2.

What each result means

C/C No copy of the version the research linked to Knee osteoarthritis. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Knee osteoarthritis. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Knee osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study

Nakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, Gomez-Reino JJ, Furuichi T, Dai J, Sudo A, Uchida A, Fukui N, Kubo M, Kamatani N

and 6 more — show all

Tsunoda T, Malizos KN, Tsezou A, Gonzalez A, Nakamura Y, Ikegawa S

PloS one · 2010 · PMID 20305777 · open access

What people read about alongside this

Infection and immunity3

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10947262

What is rs10947262?

rs10947262 is a single position in the genome, in or near the HLA-DQA2 gene. Published research associates it with knee osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10947262 linked to?

On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10947262?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10947262 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10947262 come from?

GWAS Catalog, PLoS One 2010, PMID:20305777. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Knee osteoarthritis (rs10947262). MyGeneLog™. https://www.mygenelog.com/variants/rs10947262

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