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Follicular lymphoma

HLA-DQB1 · rs10484561

Where this position leads

Condition: Follicular Lymphoma

rs10484561 Condition: Follicular Lymphoma Follicular Lymphoma Condition Topic: Infection and immunity Infection and immunity Topic rs10484561 rs10484561 HLA-DQB1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 681 European ancestry cases, 750 European ancestry controls; replicated in up to 3,164 European ancestry cases, 6,208 European ancestry controls.

The effect Each copy of the G allele carried 1.95 times the odds of Follicular lymphoma (95% confidence interval 1.72-2.22); p = 1 × 10−29.

How common The G allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 8.5 kb from MTCO3P1.

What each result means

G/G Two copies of the version the research linked to Follicular lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Follicular lymphoma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Follicular lymphoma. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10484561

What is rs10484561?

rs10484561 is a single position in the genome, in or near the HLA-DQB1 gene. Published research associates it with follicular lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10484561 linked to?

On MyGeneLog this position is linked to Follicular Lymphoma. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10484561?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (5 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10484561 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10484561 come from?

GWAS Catalog, Nat Genet 2010, PMID:20639881. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Follicular lymphoma (rs10484561). MyGeneLog™. https://www.mygenelog.com/variants/rs10484561

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