PRKD2 · rs11083846
Where this position leads
Condition: Chronic Lymphocytic Leukaemia
What the study found
Who was studied 505 European ancestry cases, 1,438 European ancestry controls; replicated in 1,024 European ancestry cases, 1,677 European ancestry controls.
The effect Each copy of the A allele carried 1.35 times the odds of Chronic lymphocytic leukemia (95% confidence interval 1.22-1.49); p = 4 × 10−9.
How common The A allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — at a splice region of PRKD2.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2019-05-30.
ClinVar record 1242551 NM_016457.5(PRKD2):c.667-6C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs11083846 is a single position in the genome, in or near the PRKD2 gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2008, PMID:18758461. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Chronic lymphocytic leukemia (rs11083846). MyGeneLog™. https://www.mygenelog.com/variants/rs11083846