TERT · rs2242652
Where this position leads
Condition: Prostate Cancer
What the study found
Who was studied 6,621 European ancestry cases, 6,939 European ancestry controls; replicated in 22,957 European ancestry cases, 23,234 European ancestry controls, 420 East Asian ancestry cases, 433 East Asian ancestry controls, 112 African American cases, 298 African American controls, 7,140 cases, 5,455 controls.
The effect Each copy of the G allele carried 1.15 times the odds of Prostate cancer (95% confidence interval 1.11-1.19); p = 3 × 10−24.
How common The G allele had a frequency of about 81% in the people studied.
Where it sits Chromosome 5, band 5p15.33 — in an intron of TERT.
What ClinVar records
Classification
Benign for Dyskeratosis congenita, autosomal dominant 2, Idiopathic Pulmonary Fibrosis; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2026-01-26.
ClinVar record 539266 NM_198253.3(TERT):c.1950+245C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
2026-08-08 · Prokunina-Olsson L, et al. Nature Communications 2026, PMID:42706231
Newly curated by the GWAS Catalog: 141 associations across 1 trait ("Bladder cancer"), from Prokunina-Olsson L, et al. in Nature Communications, 2026. Sample in the catalogue's record: 30,156 cases and 1,527,568 controls. Of its 70 positions, 33 already have pages here — 16 on the Bladder Cancer page; 1 on the Lung Cancer page; 1 on the Ulcerative Colitis page — including rs2294008 (PSCA), rs10094872 (MYC), rs2242652 (TERT). Put together by code from the catalogue's records; for anything more, follow the link to the paper. PMID:42706231.
rs2242652 is a single position in the genome, in or near the TERT gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), infection and immunity (1 papers), liver (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2011, PMID:21743467. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Prostate cancer (rs2242652). MyGeneLog™. https://www.mygenelog.com/variants/rs2242652