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Primary biliary cholangitis

IL12A · rs6441286

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cholangitis compared to the general population. (GWAS Catalog, Nat Genet 2010, PMID:20639880)

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cholangitis. (GWAS Catalog, Nat Genet 2010, PMID:20639880)

T/T Published research associates this genotype with typical/baseline likelihood of Primary biliary cholangitis — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2010, PMID:20639880)

Source: GWAS Catalog, Nat Genet 2010, PMID:20639880

Questions about rs6441286

What is rs6441286?

rs6441286 is a single position in the genome, in or near the IL12A gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6441286 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6441286 come from?

GWAS Catalog, Nat Genet 2010, PMID:20639880. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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