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Who was studied 453 European ancestry cases, 945 European ancestry controls,; replicated in 481 European ancestry cases, 3,706 European ancestry controls.
The effect
Each copy of the G allele carried 1.44 times the odds of Primary biliary cholangitis; p = 8 × 10−12.
How common The G allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 3, band 3q25.33 — in an intron of IL12A-AS1.
What each result means
G/GTwo copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs6441286
What is rs6441286?
rs6441286 is a single position in the genome, in or near the IL12A gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6441286 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs6441286?
Subjects that appear in the title or abstract of the same papers as this rsID include liver (2 papers), gut and food intolerance (1 papers), infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs6441286 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6441286 come from?
GWAS Catalog, Nat Genet 2010, PMID:20639880. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 5342146222228Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity4Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others28Total53Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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